尹教授長(zhǎng)期以來(lái)圍繞“熒光拓?fù)涓叻肿硬牧系臉?gòu)建與功能化”這一高分子材料領(lǐng)域的重要前沿課題，開(kāi)展了熒光功能高分子的設(shè)計(jì)/合成以及生物應(yīng)用的系統(tǒng)研究。熒光小分子化合物一般具有疏水的共軛結(jié)構(gòu)，在生物或極性介質(zhì)中容易聚集，導(dǎo)致熒光衰減或猝滅。此外，傳統(tǒng)高分子載體不含有熒光基團(tuán)，很難在細(xì)胞內(nèi)起到標(biāo)記、示蹤的作用。因此，需要解決的關(guān)鍵科學(xué)問(wèn)題是既要確保熒光分子具有水溶性、光穩(wěn)定性，又要賦予熒光分子一定的生物相容性、特異功能性。針對(duì)以上關(guān)鍵問(wèn)題，尹梅貞教授將熒光發(fā)色基團(tuán)與拓?fù)涔δ芨叻肿佑袡C(jī)結(jié)合起來(lái)，提出了將拓?fù)涔δ芨叻肿幼鳛橥鈬鷼けＷo(hù)和隔離疏水熒光核的新策略，構(gòu)建了系列核-殼熒光拓?fù)涓叻肿硬牧?，解決了水溶性與光穩(wěn)定性差的難題。在此基礎(chǔ)上，發(fā)明了新型熒光抗癌藥物分子以及多種特異性熒光分子探針，使其具有“熒光示蹤”和“納米載體”雙功能 ，開(kāi)創(chuàng)性地建立了將熒光納米載體用于農(nóng)業(yè)害蟲(chóng)防治新技術(shù)，成功地?cái)y帶基 因/藥物/蛋白應(yīng)用于農(nóng)作物害蟲(chóng)綠色防控等，為避免化學(xué)農(nóng)藥的過(guò)度使用打開(kāi)了綠色生物防治新思路。研究工作帶動(dòng)了熒光標(biāo)記以及抗腫瘤研究領(lǐng)域的 發(fā)展，引領(lǐng)化學(xué)與生命醫(yī)學(xué)以及農(nóng)業(yè)交叉學(xué)科研究，具有重要的學(xué)術(shù)價(jià)值以及實(shí)際應(yīng)用前景。例如，美國(guó)國(guó)立研究院Nard Kubben研究員，美國(guó)約翰霍 普金斯大學(xué)Jan H. Hoh教授，以及德國(guó)美因茨大學(xué)Gert O. Pflugfelder教 授，采用尹教授團(tuán)隊(duì)構(gòu)建的熒光分子用于他們的生物學(xué)示蹤等生命科學(xué)研究 。安貞醫(yī)院心血管重大疾病協(xié)同創(chuàng)新中心（2011協(xié)同創(chuàng)新中心）杜杰教授團(tuán)隊(duì)使用尹教授團(tuán)隊(duì)的熒光抗癌藥物分子進(jìn)行癌癥早期診斷研究。中國(guó)農(nóng)業(yè)大學(xué)，華南農(nóng)業(yè)大學(xué)等農(nóng)業(yè)高校研究人員使用尹教授提供的熒光高分子材料從事他們各自領(lǐng)域的不同種類(lèi)昆蟲(chóng)遺傳學(xué)等研究。
近期發(fā)表文章
1. M. Sun, K. Müllen, M. Yin*, Water-soluble perylenediimides: design concepts and biological applications,Chem. Soc. Rev., DOI:10.1039c5cs00754b. (IF=33.383)
2. K. Liu, Z. Xu, M. Yin*, Perylenediimide-Cored Dendrimers and Their Bioimaging and Gene Delivery Applications,Prog. Polym. Sci., 2015, 46, 25–54. (IF=26.932)
3. M. Chen,M. Yin*, Design and Development of Fluorescent Nanostructures for Bioimaging, Prog. Polym. Sci., 2014, 39, 365–39. (IF=26.932)
4. Y. Zheng, S. You, C. Ji, M. Yin*, W. Yang, J. Shen*, Development of an Amino Acid-Functionalized Fluorescent Nanocarrier to Deliver a Toxin to Kill Insect Pests, Adv. Mater., 2016, 28, 1375–1380. (IF=17.493)
5. B. He, Y. Chu, M. Yin*, K. Müllen, C. An*, J. Shen*, Fluorescent Nanoparticle Delivered dsRNA toward Genetic Control of Insect Pest,Adv. Mater., 2013, 25, 4580–4584. (IF=17.493)
6. S. Wan, Z. Ma, C. Chen, F. Li, F. Wang, X. Jia, W. Yang, M. Yin*, A Supramolecule-Triggered Mechanochromic Switch of Cyclodextrin-jacketed Rhodamine and Spiropyran Derivatives, Adv. Func. Mater., 2016, 26, 353–364. (IF=11.805)
7. J. Li, B. Lv, D. Yan, S. Yan, M. Wei, M. Yin*, Tunable Self-assembled Micro/nanostructures of Carboxyl-Functionalized Squarylium Cyanine for Ammonia Sensing, Adv. Func. Mater., 2015, 25, 7442–7449. (IF=11.805)
8. R. Liang, S. You, L. Ma, C. Li, R. Tian, Min Wei*, Dan Yan*, M. Yin*, W. Yang, D. G. Evans, X. Duan, A Supramolecular Nanovehicle toward Systematic, Targeted Cancer and Tumor Therapy, Chem. Sci., 2015, 6, 5511–5518 (IF=9.211)
9. Z. Xu, K. Guo, J. Yu, H. Sun, J. Tang, J. Shen, K. Müllen, W. Yang, M. Yin*, A Unique Perylene-Based DNA Intercalator: Localization in Cell Nuclei and Inhibition of Cancer Cells and Tumors, Small, 2014, 10(20), 4087–4092. (IF=8.368)
10. J. Li, K. Guo, J. Shen, W. Yang, M. Yin*, A Difunctional Squarylium Indocyanine Dye Distinguishes Dead Cells through Diverse Staining of the Cell Nuclei/Membranes, Small, 2014, 10(7), 1351–1360. (IF=8.368)
11. M. Chen, W. Yang*,M. Yin*, Size-controllable Synthesis and Functionalization of Ultrafine Polymeric Nanoparticles,Small, 2013, 9, 2715–2719. (IF=8.368)
12. M. Sun, W. Yin,* X. Dong, W. Yang, Y. Zhao,M. Yin*, Fluorescent Supramolecular Micelles for Imaging-Guided Cancer Therapy, Nanoscale, 2016, DOI:10.1039/C6NR00450D. (IF=7.394)
13. X. Liu, B. He, Z. Xu, M. Yin*, W. Yang, W. Wei, H. Zhang, J. Cao, J. Shen*, Functionalized fluorescent dendrimer as pesticide nanocarrier: application in pest control, Nanoscale, 2015, 7, 445–449. (IF= 7.394)
14. Y. Lu, B. He, J. Shen, J. Li, W. Yang, M. Yin*, Multifunctional magnetic and ?uorescent core–shell nanoparticles for bioimaging, Nanoscale, 2015, 7, 1606–1609 (IF=7.394).
15. L. Jiang, L. Ding, B. He, J. Shen*, Z. Xu,M. Yin*, X. Zhang*, Systemic gene silencing in plants triggered by ?uorescent nanoparticle-delivered double-stranded RNA, Nanoscale, 2014, 6, 9965–9969. (IF=7.394)
16. Meizhen Yin*, C. Feng, J. Shen, Y. Yu, Z. Xu, W. Yang, W. Knoll, K. Müllen*, Dual-responsive Interaction to Detect DNA on Template-based Fluorescent Nanotubes, Small, 2011, 7, 1629–1634. (IF=8.368)
17.
Meizhen Yin*, J. Shen, W. Pisula, M. Liang, L. Zhi, K. Müllen
*, Functionalization of Self-Assembled Hexa-peri-hexabenzocoronene Fibers with Peptides for Bioprobing,
J. Am. Chem. Soc., 2009, 131, 14618–14619. (IF=
12.113)
18.Meizhen Yin, Y. Cheng, M. Liu, J. S. Gutmann, K. Müllen*, Nanostructured Ultrathin Anatase TiO2 Films Templated by Amphiphilic Core-Shell Nanoparticle, Angew. Chem. 2008, 120, 8528-8531, Angew. Chem. Int. Ed., 2008, 47, 8400–8403. (IF=11.261)
19. Meizhen Yin, J. Shen*, G. O. Pflugfelder, K. Müllen*, A Fluorescent Core-shell Dendritic Macromolecule Specifically Stains the Extracellular Matrix,J. Am. Chem. Soc., 2008, 130, 7806–7807. (IF=12.113)
20. Meizhen Yin, J. Shen*, R. Gropeanu, G. O. Pflugfelder, T. Weil, K. Müllen*, Fluorescent Core/Shell Nanoparticles for Specific Cell-Nucleus Staining, Small, 2008, 4, 894–898. (IF=8.368)
