Disassembly of Multicompartment Polymer Micelles in Spatial Sequence Using an Electrostatic Field and Its Application for Release in Chronological Order
作者：Wu, Ming.; Zhu, Yutian; Jiang, Wei
關(guān)鍵字：Multicompartment micelles
論文來源：期刊
發(fā)表時(shí)間：2018年
Multicompartment micelles (MCPs), comprising
sequences of repeated elemental discoid parts connected by
fasciculus, were formed by self-assembly of polystyrene-blockpoly(
2-vinyl pyridine)-block-poly(ethylene oxide). Using an
electrostatic field, the MCPs can be disassembled through
consequent release of small spherical micelles. During this
disassembly process, release of loaded species can be achieved
from the micelles in chronological order. Two location-selected
cargos (mitoxantrone (MTNT) and fluorescein isothiocyanate
(FITC)) in the outer and inner compartments of the micelles
can be released in chronological order. Under the applied
electrostatic field (intensity: 16 kVcm1), the loaded MTNT
was rapidly released with more than 80% release, whereas the
loaded FITC was slowly released with less than 20%release in
12 h. At a later stage (after more than 12 h), the loaded MTNT
was slowly released with less than 20% release, while the
loaded FITC was rapidly released with more than 80%release