Controlled Topological Structure of Copolyphosphates by Adjusting Pendant Groups of Cyclic Phosphate Monomers
作者：(33) Liu, J. Y.; Pang, Y.; Huang, W.*; Zhai, X.; Zhu, X. Y.; Zhou, Y. F.; Yan, D. Y.*
關(guān)鍵字：Controlled Topological Structure,Cyclic Phosphate Monomers
論文來(lái)源：期刊
具體來(lái)源：Macromolecules 2010, 43, 8416. http://pubs.acs.org/doi/pdf/10.1021/ma1015819
發(fā)表時(shí)間：2010年
A convenient method was reported to control the topological structure of
copolyphosphates by adjusting the pendant group of cyclic phosphate
monomers (CPMs) in the ring-opening polymerization (ROP), including
linear block, star block, and hyperbranched multiarm structure. Linear
block copolyphosphate (PEP-b-PIPP) was prepared by a two-step ROP
procedure of CPMs with different pedant groups, i.e., monofunctional
propargyl alcohol first initiated the ROP of the CPM with ethyl and then
the CPM with isopropyl in turn. Similarly, star block copolyphosphate
(SPEP-b-PIPP) was also synthesized when the monofunctional
propargyl alcohol was replaced by a trifunctional trimethylolpropane.
When the pendant group of CPM was changed into 2-hydroxyethyl,
hyperbranched polyphosphate (HPHEP) was obtained first through the
self-condensing ring-opening polymerization (SCROP) of such CPM, and
then the terminal hydroxyls of HPHEP further initiated the ROP of CPM
with ethyl to produce hyperbranched multiarm copolyphosphate (HPHEP-star-PEP).
The resulting copolyphosphates were characterized by NMR, GPC, FTIR,
and DSC techniques in detail, and the results confirmed their
topological structures. Moreover, methyltetrazolium assay and AO/EB
double staining methods indicated that all copolyphosphates with
different topological structures had excellent biocompatibility against
NIH 3T3 cells and would be applied as novel biomedical materials.