Fabrication, crystalline behavior, mechanical property and in-vivo degradation of poly(L-lactide) (PLLA)–magnesium oxide whiskers (MgO) nanocomposites prepared by in-situ polymerization
作者：Liang Hui, Zhao Yun, Yang Jinjun, Li Xiao, Yang Xiaoxian, Sasikumar Yesudass, Zhou Zhiyu, Chen Minf
關鍵字：機械性能，體外降解， 原位聚合
論文來源：期刊
具體來源：Polymers
發表時間：2019年
The present work focuses on the preparation of poly(l–lactide)–magnesium oxide whiskers
(PLLA–MgO) composites by the in-situ polymerization method for bone repair and implant.
PLLA–MgO composites were evaluated using Fourier transform infrared spectroscopy (FTIR), X-ray di raction (XRD), di erential scanning calorimetry (DSC), scanning electron microscopy (SEM) and solid-state 13C and 1H nuclear magnetic resonance spectroscopy (NMR). It was found that the whiskers were uniformly dispersed in the PLLA matrix through the interfacial interaction bonding between PLLA and MgO; thereby, the MgO whisker was found to be well-distributed in the PLLA matrix, and biocomposites with excellent interface bonding were produced. Notably, the MgO whisker has an e ect on the crystallization behavior and mechanical properties; moreover, the in vivo degradation of PLLA–MgO composites could also be adjusted by MgO. These results show that the whisker content of 0.5 wt % and 1.0 wt % exhibited a prominent nucleation e ect for the PLLA matrix, and specifically 1.0 wt % MgO was found to benefit the enhanced mechanical properties greatly. In addition, the improvement of the degrading process of the composite illustrated that the MgO whisker can e ectively regulate the degradation of the PLLA matrix as well as raise its bioactivity. Hence, these results demonstrated the promising application of PLLA–MgO composite to serve as a biomedical material for bone-related repair.