A transparent wound dressing based on bacterial cellulose whiskerand poly(2-hydroxyethyl methacrylate)
作者：Zeng Dia,b,1, Zhijun Shia,b,1, Muhammad Wajid Ullaha,b, Sixiang Lia,b, Guang Yanga,b,.
關鍵字：BC whisker、Hydrogel、Antibacterial properties,Transparent wound dressing
論文來源：期刊
具體來源：Biological Macromolecules
發表時間：2017年
The current study was aimed to develop a transparent wound dressing comprised of bacterial cellulose(BC) and poly (2-hydroxyethyl methacrylate) (PHEMA) hydrogel coated with silver (Ag) nanoparticles.Briefly, different concentrations of BC whiskers (BCWs) were added into the HEMA solution to formPHEMA/BCWs hydrogel with volume ratio of monomer HEMA and BCWs as 7:3 and 1:1. The addition ofBCWs into PHEMA matrix improved its equilibrium water content and light transmittance about 20%-40%and 10%, respectively. The Young’s modulus for PHEMA was found to be 0.72 MPa, which was improvedto 0.57 MPa and 0.50 MPa for PHEMA/BCWs 7:3 and PHEMA/BCWs 1:1, respectively. Further, immersionof PHEMA/BCWs hydrogel in the AgNO3and NaBH4solutions bestowed it with antibacterial property andproduced inhibition zones of 0.5 ± 0.15 cm and 0.25 ± 0.15 cm against Escherichia coli and Staphylococcusaureus, respectively. Similarly, PHEMA/BCWs prepared with 0.001 M AgNO3and 0.001 M NaBH4solutionsshowed 99% and 90% reduction in colony forming unit (CFU) for E. coli and S. aureus, respectively, after 24 h.The PHEMA/BCWs/Ag hydrogel facilitated the growth of NIH3T3 fibroblast, showing their low toxicity.These results demonstrate the suitability of PHEMA/BCWs/Ag hydrogel for its application as potentialtransparent wound dressing material for skin repair.