Reversible grafting of antibiotics onto contact lens mediated by labile chemical bonds for smart prevention and treatment of corneal bacterial infections
writer：Bailiang Wang, Jiahong Zeng, Yishun Guo, Lin Liang, Yingying Jin, Siyuan Qian, Renjie Miao, Liang Hu
keywords：contact lens, corneal infections,dynamic chemical bonds,schiff base reaction,multilayer films
source：期刊
Issue time：2020年
Eye trauma, decreased immunity, and contact lens wear often cause serious bacterial infections and irreversible corneal damage. To realize the responsive release of antibiotics such as gentamicin sulfate (GS), a novel antibacterial contact lens was constructed through self-assembly of antibiotics loaded ADA-GS/PEI (polyethyleneimine) multilayer films on the surface. Both in vitro and in vivo antibacterial tests demonstrated high efficient and fast antibacterial property based on the smart responsive to bacterial infections and reversible drug loading and release.