[Beilstein J. Org. Chem.] Linear-g-hyperbranched and cyclodextrin-based amphiphilic block copolymer as a multifunctional nanocarrier
writer：Yamei Zhao, Wei Tian*, Guang Yang and Xiaodong Fan
keywords：Amphiphilic block copolymer，multifunctional nanocarrier
source：期刊
specific source：Beilstein J. Org. Chem., 2014, 10, 2696–2703.
Issue time：2014年
In this paper, a novel, multifunctional polymer nanocarrier was designed to provide adequate volume for high drug loading, to afford a multiregion encapsulation ability, and to achieve controlled drug release. An amphiphilic, triblock polymer (ABC) with hyperbranched polycarbonsilane (HBPCSi) and β-cyclodextrin (β-CD) moieties were first synthesized by the combination of a twostep reversible addition-fragmentation transfer polymerization into a pseudo-one-step hydrosilylation and quaternization reaction. The ABC then self-assembled into stable micelles with a core–shell structure in aqueous solution. These resulting micelles are multifunctional nanocarriers which possess higher drug loading capability due to the introduction of HBPCSi segments and β-CD moieties, and exhibit controlled drug release based on the diffusion release mechanism. The novel multifunctional nanocarrier may be applicable to produce highly efficient and specialized delivery systems for drugs, genes, and diagnostic agents.
全文鏈接：http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273233/