【Nature Communications】Heparin-Network-Mediated Long-lasting Coatings on Intravascular Catheters for Adaptive Antithrombosis and Antibacterial lnfection（IF=16.6，中科院一區）
作者：Lin Liu, Huan Yu, Lei Wang, Dongfang Zhou, Jinghua Yin, Shifang Luan*, Hengchong Shi*.
關鍵字：Heparin，Intravascular
論文來源：期刊
具體來源：Nature Communications
發表時間：2024年
Abstract:
Bacteria-associated infections and thrombosis, particularly catheter-related bloodstream infections and catheter-related thrombosis, are life-threatening complications. Herein, we utilize a concise assembly of heparin sodium with organosilicon quaternary ammonium surfactant to fabricate a multifunctional coating complex. In contrast to conventional one-time coatings, the complex attaches to medical devices with arbitrary shapes and compositions through a facile dipping process and further forms robust coatings to treat catheter-related bloodstream infections and thrombosis simultaneously. Through their robustness and adaptive dissociations, coatings not only exhibit good stability under extreme conditions but also significantly reduce thrombus adhesion by 60% and broad-spectrum antibacterial activity (>97%) in vitro and in vivo. Furthermore, an ex vivo rabbit model verified that the coated catheter has the potential to prevent catheter-related bacteremia during implantation. This substrate-independent and portable long-lasting multifunctional coating can be employed to meet the increasing clinical demands for combating catheter-related bloodstream infections and thrombosis.