Photo-switchable supramolecular comb-like polymer brush based on host–guest recognition for use as antimicrobial smart surface.
作者：Si Yu Zheng, Yifeng Ni , Jiahui Zhou , Yucong Gu, Yiting Wang, Jingfeng Yuan, Xiaoyu Wang, Dong
關鍵字：Azobenzene (azo)-modified
論文來源：期刊
發表時間：2024年
Bacterial infections from biomedical devices pose a great threat to the health of humans and thus place a heavy burden on society. Therefore, developing efficient antibacterial surfaces has attracted much attention. However, it is a challenge to identify or develop a combination that efficiently integrates multiple functions via topological tailoring and on-demand function-switch via non-contact and noninvasive stimuli. To resolve this issue, a highly hydrophilic comb polymer brush was constructed here based on supramolecular host–guest recognition. Azobenzene (azo)-modified antifouling and antibacterial polymers were incorporated into cyclodextrin (CD)-modified antifouling polymer brushes grafted on the surface. The surface thus obtained possessed excellent antifouling performance with a low bacterial density of ～6.25 × 105 cells per cm2 after 48 h and exhibited a high efficiency of ～88.2% for killing bacteria. Besides, irradiation with UV light resulted in the desorption of the azo-polymers and a release of ～85.1% attached bacteria. Irradiating visible light led to the re-adsorption of azo-polymers, which regenerated the fresh surface; the process could be repeated for at least three cycles, and the surface still maintained low bacterial attachments with a cell density of ～7.10 × 105 cells per cm2, high sterilization efficiency of ～93.8%, and a bacteria release rate of ～83.1% in the 3rd cycle. The photo-switchable antibacterial surface presented in this research will provide new insights into the development of smart biomedical surfaces