作者：何乃普*, 王榮民
關(guān)鍵字：蛋白質(zhì), 水溶性高分子, 嵌段共聚物, 多糖, 非共價(jià), 自組裝
論文來源：期刊
具體來源：http://www.progchem.ac.cn/CN/abstract/abstract10773.shtml
發(fā)表時(shí)間：2012年
蛋白質(zhì)是一類具有獨(dú)特三維空間結(jié)構(gòu)的生物高分子,其分子內(nèi)部非共價(jià)鍵協(xié)同作用是形成三維空間結(jié)構(gòu)的重要驅(qū)動力。同時(shí),蛋白質(zhì)分子與其他高分子之間也可以通過非共價(jià)鍵作用實(shí)現(xiàn)自組裝。高分子鏈和蛋白質(zhì)的結(jié)構(gòu)特征是實(shí)現(xiàn)自組裝的關(guān)鍵,溶液pH值、離子強(qiáng)度以及溫度的變化會影響它們之間非共價(jià)鍵作用的類型和強(qiáng)度。本文歸納了水溶性高分子、嵌段共聚物和多糖與球狀蛋白自組裝的最新研究進(jìn)展,分別從分子結(jié)構(gòu)特征和溶液性質(zhì)等因素討論了其對高分子與蛋白質(zhì)實(shí)現(xiàn)自組裝的影響。其中,多糖與蛋白質(zhì)的非共價(jià)鍵作用是化學(xué)與生物科學(xué)交叉領(lǐng)域最為活躍的研究課題之一,通過研究蛋白質(zhì)與其他高分子的非共價(jià)鍵作用,對于理解和認(rèn)識生命過程的本質(zhì)與規(guī)律具有重要的意義,同時(shí),在材料科學(xué)、納米技術(shù)、食品科學(xué)等相關(guān)領(lǐng)域具有重要的應(yīng)用價(jià)值。
Protein is a class of major biomacromolecules with a unique three-dimensional spatial structures. The intramolecular cooperative non-covalent interactions of protein play a crucial role in formation of this structure. Meanwhile, self-assembly of protein with other polymers can be also induced by these interactions. The structures of polymer chain and protein play a key role in the self-assembly of protein with polymer. The changes of pH, ionic strength and temperature of solution affect the type and intensity of non-covalent interactions. The present review summaries the latest research on self-assembly of the water-soluble polymers, block copolymers, and polysaccharides with globular protein. The molecular structure of polymers and solution properties effecting on the self-assembly of protein with polymers are discussed in details. Especially, non-covalent interaction between polysaccharide and protein is a major research topic in interdisciplinary field between chemistry and biology. Understanding of non-covalent interactions between protein and other polymers is benefit to discover the nature and rule of life, and has important applications in materials science,