165. Red blood cell membrane-coated functionalized Cu-doped metal organic framework nanoformulations as biomimetic platform for anti-cancer therapy
作者：Luping Ren, Yanfang Sun, Junhao Zhang, Rui Wang, Lei Nie, Amin Shavandi, Khaydar E. Yunusov, Guohua
關鍵字：biomimetic nanoformulations, ZIF-8, synergistic therapy, photothermal therapy, chemotherapy, erythrocyte membrane
論文來源：期刊
具體來源：International Journal of Pharmaceutics
發表時間：2024年
Abstract: Nanoformulations for combining chemotherapy, chemodynamic therapy, and photothermal therapy have enormous potential in tumor treatment. Coating nanoformulations with cell membranes endows them with homologous cellular mimicry, enabling nanoformulations to acquire new functions and properties, including homologous targeting and long circulation in vivo, and can enhance internalization by homologous cancer cells. Herein, we fused multifunctional biomimetic nanoformulations based on Cu-doped zeolitic imidazolate framework-8 (ZIF-8). Hydroxycamptothecin (HCPT), a clinical anti-tumor drug, was encapsulated into ZIF-8, which was subsequently coated with polydopamine (PDA) and red blood cell membrane. The as-fabricated biomimetic nanoformulations showed an enhanced cell uptake in vitro and the potential to prolong blood circulation in vivo, producing effective synergistic chemotherapy, chemodynamic therapy, and photothermal therapy under the 808 nm laser irradiation. Together, the biomimetic nanoformulations showed a prolonged blood circulation and evasion of immune recognition in vivo to provide a bio-inspired strategy which may have the potential for the multi-synergistic therapy of breast cancer.
Keywords: biomimetic nanoformulations, ZIF-8, synergistic therapy, photothermal therapy, chemotherapy, erythrocyte membrane
