Langmuir--Temperature-Driven Switching of the Catalytic Activity of Artificial Glutathione Peroxidase by the Shape Transition between the Nanotubes and Vesicle-like Structures
作者：Wang, Liang; Zou, Huixin; Dong, Zeyuan; et al.
關(guān)鍵字：Catalytic Activity,Glutathione Peroxidase,Nanotubes, Vesicle-like Structures
論文來(lái)源：期刊
發(fā)表時(shí)間：2014年
Smart supramolecular nanoenzymes with temperature-driven switching property have been successfully constructed by the self-assembly of supra-amphiphiles formed by the cyclodextrin-based host–guest chemistry. The self-assembled nanostructures were catalyst-functionalized and thermosensitively-functionalized through conveniently linking the catalytic center of glutathione peroxidase and thermosensitive polymer to the host cyclodextrin molecules.The ON–OFF switches for the peroxidase activity by reversible transformation of nanostructures from tube to sphere have been achieved through changing the temperature. We anticipate that such intelligent enzyme mimics could be developed to use in an antioxidant medicine with controlled catalytic efficiency according to the needs of the human body in the future.