Photo- and pH- dually-responsive β-cyclodextrin-based supramolecular prodrug complexes self-assemblies for programmed drug delivery.
作者：Bai, Y.,* Liu, C.P., Song, X., Zhuo, L.H., Bu, H.T., Tian, W.*
關鍵字：cyclodextrins， drug delivery，host–guest systems ， self-assembly， supramolecular chemistry
論文來源：期刊
具體來源：Chemistry-an Asian Journal. 2018, 13, 3903-3911
發表時間：2018年
Despite the progress has been made in the application
of supramolecular prodrug self-assemblies to enhance the functionality of drug
delivery systems, the corresponding research on multiple responsive
supramolecular prodrug self-assemblies for programmed drug delivery is still
limited. In this paper, the synthesis and self-assembly behaviours of
supramolecular prodrug complexes (SPCs) with β-cyclodextrin-acylhydrazone-DOX and the
targeting of azobenzene-terminated poly(2-(dimethylamino)ethyl methacrylate)
(Azo-PDMA-FA) as building blocks are investigated and
described. The obtained SPCs can further form self-assemblies based on their
amphiphilic nature. Next, SPCs-based multi-compartment vesicles and complex micelles,
which are confirmed by transmission electron microscopy (TEM) and
dynamic/static light scattering (DLS/SLS), are obtained with good reversibility
under alternative visible light or UV irradiation. Furthermore, three-stage
programmed drug delivery behaviour was observed from dually responsive SPCs-based
self-assemblies utilizing UV and pH stimuli. Specifically, SPCs first
self-assembled into multi-compartment vesicles accompanied by a slow release of
DOX. Next, UV light irradiation induced the dissociation of β-CD/Azo, leading to the morphology transition and slightly enhanced release of DOX. When the self-assemblies were
transferred to PBS solution (pH 5.0), the release rates increased notably due
to the broken acylhydrazone bond. Finally, basic cell experiments further
demonstrated that the SPCs-based self-assemblies could be internalized into
cancer cells, suggesting their promise for applications in cancer therapy.