Facile construction of shape-regulated β-cyclodextrin-based supramolecular self-assemblies for drug delivery
作者：Bai, Y.,* An, N., Chen, D., Liu, Y.Z., Liu, C.P., Yao, H., Wang, C., Song, X., Tian, W.*
關鍵字：β-cyclodextrin， Drug delivery， Host-guest interaction
論文來源：期刊
具體來源：Carbohydrate Polymers. 2020, 231,115714.
發(fā)表時間：2020年
Although supramolecular prodrug self-assemblies have been proven as efficient nanocarriers for cancer therapy,tedious synthesis procedures have made their practical applications more difficult. In this paper, β-cyclodextrinbased supramolecular self-assemblies (SSAs) were directly constructed by utilizing β-cyclodextrin trimer (β-CD3)as the host unit and unmodified curcumin as the guest unit. Due to the adjustment of host-guest inclusion and hydrophilic-hydrophobic interactions occurring in the SSAs, their morphology could be readily tuned by changing the ratio of the two components. Different self-assembly morphologies, such as spherical complex micelles, spindle-like complex micelles and multi-compartment vesicles, were obtained. Furthermore, basic cell experiments were performed to study the corresponding effects of the SSA shape on their biological properties. Compared to the other micelles, the spindle-like complex micelles exhibited enhanced cellular toxicity, uptake behaviors and apoptosis rates, and the spherical complex micelles exhibited poor performance. The performance of the multi-compartment vesicles was similar to that of the spindle-like complex micelles. The facile construction of these shape-regulated SSAs and their different cellular biological properties might be valuable in the controlled drug release field.